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| The Game |
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| Although close friends at first, The Game and 50 Cent's feud was a highly publicized one, which eventually lead to one of the men from The Game's entourage being shot in the leg. The two eventually reconciliated for the public eye, but fans never believed it. |
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| 2 |
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| Rick Ross |
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| The feud started in 2009, when Rick Ross stated that apparently 50 Cent had looked at him the wrong way during the BET Awards. |
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| 3 |
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| Bang 'Em Smurf |
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| He and 50 Cent were very close friends, but when he got arrested and jailed for owning a firearm without license, 50 Cent did not bail him out. As a result Bang 'Em Smurf had to mortgage his mother's house to get the bail money and form that time there are in a continuous feud. |
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| 4 |
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| Lil Wayne |
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| The feud between these two was, as some say, purely fiction as they needed the publicity. It started in 2007 and ended in 2009 when 50 Cent appeared and performed at Lil Wayne's America's Most Wanted Musical Festival stop in Anaheim, California. |
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| 5 |
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| Young Buck |
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| This particular feud seemed to be other money and loyalty. Young Buck was part of G-Unit until 50 Cent kicked him out in 2008. Apparently, Young Buck did not only owe 50 Cent money, but he appeared in the video of one of 50 Cent's former rivals, The game. |
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| 6 |
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| Ja Rule |
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| 50 Cent stated that a friend robbed Ja Rule of his jewelry and that Ja Rule accused him of setting it up. |
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